While on my Sorcerer/Thaumateurge/Frost Mage today, I was running the Nashkel supplies quest back to Beregost, and was surprised to have half a dozen of Beregosts NPC citizens turn hostile and try to pummel my gnome as I ran towards the Inn
I'll try and give as much detail as I can about what buffs I had up. Also, and I don't know if this is relevant, I had just fought 3 wyverns, testing my bigbys spells on them and summoning 3 hands, before entering Beregost... and it occurs to me that I did hit my summoned bigbys hands with maximized ice storms and killed 1 or 2 of them in the process(as well as using maximized ice darts and magic missiles on the wyverns). Perhaps that had something to do with it?
In any case, the spells I had up were:
Prot. from evil, Imp. mage armor, Spiderskin, Mirror image, Extended Shield, Superior resistance, Extended Shadow Shield, Premonition, Energy immunity: fire, and Extended haste.